http://pedagoglar.uz/index.php/ped/issue/feedPEDAGOGS jurnali2024-07-23T15:23:54+00:00Pedagoglar.Uzinfo@pedagoglar.uzOpen Journal Systems<p><strong>PEDAGOGS </strong>jurnali har oyda ikki marotaba elektron shaklda chop etiladigan xalqaro elektron jurnal hisoblanadi. Jurnalda barcha yosh izlanuvchilar, talabalar, magistrlar, yosh professor va doktorantlar hamda o'rta ta'lim muassasalari hodimlari o'z ilmiy ishlarini chop qilishlari mumkin.</p> <p><strong>Jurnal faoliyatining asosiy maqsadi:</strong> Mamlakatimizdagi yosh izlanuvchilarini zamonaviy ilg‘or qarashlar bilan tanishtirish, ilmiy faoliyatlarini jonlantirish, davlat ilmiy nufuzi va salohiyatini o‘stirish, turli innovatsion tadqiqotlarda ishtirok etishini kuchaytirish, tadqiqotlarning ilmiy-amaliy ahamiyatini yanada oshirish va ularni keng ommaga yetkazish.</p> <div class="subjects_title"><strong>“PEDAGOGS”</strong> jurnali quyidagi yo'nalishlar bo'yicha tadqiqot natijalarini qamrab oladi:</div> <div class="row"> <div class="col-md-6 col-sm-6 col-xl-6 col-xxl-6"> <ul> <li class="subject_list"><em>Aniq fanlar</em></li> <li class="subject_list"><em>Tabiiy fanlar</em></li> <li class="subject_list"><em>Texnika fanlari</em></li> <li class="subject_list"><em>Pedagogik fanlar</em></li> <li class="subject_list"><em>Ijtimoiy-gumanitar fanlar</em></li> <li class="subject_list"><em>Falsafa fanlari</em></li> <li class="subject_list"><em>Filologiya</em></li> <li class="subject_list"><em>Iqtisodiy fanlar</em></li> </ul> <p><em><strong>Har qanday hamkorllik uchun biz bilan bog'laning.</strong></em></p> </div> </div>http://pedagoglar.uz/index.php/ped/article/view/7156THE CATEGORIES OF ONOMASTICS IN MODERN LINGUISTICS2024-07-23T15:23:38+00:00Farmanov Gayrat Khujakulovich info@pedagoglar.uz<p><strong>Abstract: </strong>In this article,Onomastics is the study of proper names. It deals of functional-semantic properties of onomastics . In addition, in the process of studying the composition of onomastics, it determines that the formation of the name and it is a factor that provides information about the categories of onomastics.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7242THE CATEGORIES OF ONOMASTICS IN MODERN LINGUISTICS2024-07-23T15:23:54+00:00Farmanov Gayrat Khujakulovich info@pedagoglar.uz<p><strong>Abstract: </strong>In this article,Onomastics is the study of proper names. It deals of functional-semantic properties of onomastics . In addition, in the process of studying the composition of onomastics, it determines that the formation of the name and it is a factor that provides information about the categories of onomastics.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7241ONOMASTICS AS A BRANCH OF LINGUISTICS2024-07-23T15:23:53+00:00Farmanov Gayrat Khujakulovichinfo@newjournal.org<p><strong>Abstract.</strong> This article examines, analyzes, and discusses the specifics of linguistics as a research object, the place of onomastics in Uzbek linguistics today, and its future prospects.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7149ONOMASTICS AS A BRANCH OF LINGUISTICS2024-07-23T15:23:37+00:00Farmanov Gayrat Khujakulovichinfo@newjournal.org<p><strong>Abstract.</strong> This article examines, analyzes, and discusses the specifics of linguistics as a research object, the place of onomastics in Uzbek linguistics today, and its future prospects.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7140ОЦЕНКА ВОСПРИЯТИЯ ТЕХНОЛОГИЧЕСКИХ ИННОВАЦИЙ РУКОВОДЯЩИМИ КАДРАМИ ВУЗОВ: МЕТОДИКА И РЕЗУЛЬТАТЫ ЭКСПЕРИМЕНТА2024-07-23T15:23:36+00:00В.А.Каримоваinfo@pedagoglar.uz<p> </p> <p><strong>Аннотация. </strong>В данной статье представлен анализ эксперимента, проведенного среди руководящих кадров высших образовательных учреждений, обучающихся по программе повышения квалификации в сфере 'Менеджмент системы образования'. Целью исследования являлось оценка восприятия и отношения к технологическим инновациям в образовательной сфере. Методология исследования включает серию педагогических приемов, нацеленных на стимулирование обсуждения и критического анализа существующих и потенциальных технологий в высшем образовании. Основное внимание в эксперименте уделялось анализу изменений и дополнений, внесенных слушателями в модели восприятия различных технологических концепций. Результаты показали активное участие и интерес участников к новшествам, особенно в контексте будущего применения технологий. Исследование подчеркивает важность непрерывного повышения квалификации и адаптации к быстро меняющимся технологическим трендам в высшем образовании.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7240ОЦЕНКА ВОСПРИЯТИЯ ТЕХНОЛОГИЧЕСКИХ ИННОВАЦИЙ РУКОВОДЯЩИМИ КАДРАМИ ВУЗОВ: МЕТОДИКА И РЕЗУЛЬТАТЫ ЭКСПЕРИМЕНТА2024-07-23T15:23:53+00:00В.А.Каримоваinfo@pedagoglar.uz<p> </p> <p><strong>Аннотация. </strong>В данной статье представлен анализ эксперимента, проведенного среди руководящих кадров высших образовательных учреждений, обучающихся по программе повышения квалификации в сфере 'Менеджмент системы образования'. Целью исследования являлось оценка восприятия и отношения к технологическим инновациям в образовательной сфере. Методология исследования включает серию педагогических приемов, нацеленных на стимулирование обсуждения и критического анализа существующих и потенциальных технологий в высшем образовании. Основное внимание в эксперименте уделялось анализу изменений и дополнений, внесенных слушателями в модели восприятия различных технологических концепций. Результаты показали активное участие и интерес участников к новшествам, особенно в контексте будущего применения технологий. Исследование подчеркивает важность непрерывного повышения квалификации и адаптации к быстро меняющимся технологическим трендам в высшем образовании.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7239MA’MURIY NAZORAT VA PROFILAKTIK HISOB INSTITUTINI BEKOR QILGAN HOLDA PROFILAKTIK NAZORAT INSTITUTINI JORIY QILISH2024-07-23T15:23:52+00:00Shaxboz Ne’matjonov Ne’matjon o’g’liinfo@pedagoglar.uzShaxboz Ne’matjonov Ne’matjon o’g’liinfo@pedagoglar.uz<p>Maqolada Ma‘muriy nazorat hamda profilaktik hisobga olingan shaxslar bilan profilaktik suhbat o‘tkazish, hisobga qo‘yish va hisobdan chiqarish tartibini amalga oshirish usullari, profilaktik hisobda turgan shaxslarga nisbatan yurtilgan profilaktik hisobni amalga oshirish tartibi va shu kabi boshqa holatlar ilmiy tahlil qilingan hamda bu borada tegishli takliflar ilgari surilgan.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7134MA’MURIY NAZORAT VA PROFILAKTIK HISOB INSTITUTINI BEKOR QILGAN HOLDA PROFILAKTIK NAZORAT INSTITUTINI JORIY QILISH2024-07-23T15:23:35+00:00Shaxboz Ne’matjonov Ne’matjon o’g’liinfo@pedagoglar.uzShaxboz Ne’matjonov Ne’matjon o’g’liinfo@pedagoglar.uz<p>Maqolada Ma‘muriy nazorat hamda profilaktik hisobga olingan shaxslar bilan profilaktik suhbat o‘tkazish, hisobga qo‘yish va hisobdan chiqarish tartibini amalga oshirish usullari, profilaktik hisobda turgan shaxslarga nisbatan yurtilgan profilaktik hisobni amalga oshirish tartibi va shu kabi boshqa holatlar ilmiy tahlil qilingan hamda bu borada tegishli takliflar ilgari surilgan.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7127MAKTABDA ZAMONAVIY GEOGRAFIK MAYDONCHA2024-07-23T15:23:34+00:00Sattorov Daler Alisher o'g'liinfo@web-journal.ru<p><strong>Annotatsiya:</strong> Maqolada Zamonaviy geografik maydoncha, uning geografiya fanini o'qitishda tutgan o'rni, maydonchada jolashtiriladigan o'quv jihozlari va ularning ahamiyati yoritilgan.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7238MAKTABDA ZAMONAVIY GEOGRAFIK MAYDONCHA2024-07-23T15:23:52+00:00Sattorov Daler Alisher o'g'liinfo@web-journal.ru<p><strong>Annotatsiya:</strong> Maqolada Zamonaviy geografik maydoncha, uning geografiya fanini o'qitishda tutgan o'rni, maydonchada jolashtiriladigan o'quv jihozlari va ularning ahamiyati yoritilgan.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7237IMAGE-TO-VIDEO CONVERSION: BRIDGING STATIC VISUALS TO DYNAMIC NARRATIVES 2024-07-23T15:23:52+00:00 Chulliyev Shokhrukh Ibadullayevichinfo@web-journal.ru<p><strong>Abstract: </strong>Image-to-video conversion is a transformative process that translates a sequence of still images into a dynamic and cohesive video format. It involves organizing, sequencing, and enhancing individual images with transitions and audio elements to create engaging visual narratives. This technology's versatility finds applications across marketing, digital content creation, education, and entertainment, offering a creative means to transform static visuals into compelling video presentations. As technology advances, automated tools and AI-driven algorithms continue to refine and streamline this conversion process, enabling efficient and captivating video creation from static imagery.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7121IMAGE-TO-VIDEO CONVERSION: BRIDGING STATIC VISUALS TO DYNAMIC NARRATIVES 2024-07-23T15:23:33+00:00 Chulliyev Shokhrukh Ibadullayevichinfo@web-journal.ru<p><strong>Abstract: </strong>Image-to-video conversion is a transformative process that translates a sequence of still images into a dynamic and cohesive video format. It involves organizing, sequencing, and enhancing individual images with transitions and audio elements to create engaging visual narratives. This technology's versatility finds applications across marketing, digital content creation, education, and entertainment, offering a creative means to transform static visuals into compelling video presentations. As technology advances, automated tools and AI-driven algorithms continue to refine and streamline this conversion process, enabling efficient and captivating video creation from static imagery.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7236UMUMIY O’RTA TA’LIM MUASSASALARIDA O’QUVCHILAR OVQATLANISHINI GIGIYENIK TASHKILLASHTIRISH2024-07-23T15:23:51+00:00Soatov Mirmuhsin Maxmatmurot o’g’li info@web-journal.ruSoatov Mirmuhsin Maxmatmurot o’g’li info@pedagoglar.uz<p>Bugungi kunda ko'plab kasalliklarning oldini olish, aholi salomatligini saqlash va mustahkamlashning eng muhim shartlaridan biri bo'lgan sog'lom turmush tarzi tamoyillariga asoslanadi. Shu bilan birga, asosiy vazifalardan biri parhez ovqatlanish va ozuqa moddalar tarkibini optimallashtirish, aholi guruhlari va avvalambor, bolalar va o'smirlarning sog'lig'ini saqlash va yaxshilashdir. Ishning maqsadi umumiy o’rta ta’lim muassasalari o’quvchilarini sog’lom ovqatlanishini gigienik baholash va ularni optimallashtirish bo'yicha tavsiyalarni ilmiy asoslashdir. Aniqlanishicha, ovqatlanishda sanitariya qoida va me’yorlar bo'yicha bilimlarning yetarli emasligi bolalar va o'smirlarning ovqatlanishini tashkil etishdagi mavjud kamchiliklar, shuningdek iqtisodiy omillar tufayli ovqatlanish holatining yetarli emasligiga olib keladi.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7115UMUMIY O’RTA TA’LIM MUASSASALARIDA O’QUVCHILAR OVQATLANISHINI GIGIYENIK TASHKILLASHTIRISH2024-07-23T15:23:32+00:00Soatov Mirmuhsin Maxmatmurot o’g’li info@web-journal.ruSoatov Mirmuhsin Maxmatmurot o’g’li info@pedagoglar.uz<p>Bugungi kunda ko'plab kasalliklarning oldini olish, aholi salomatligini saqlash va mustahkamlashning eng muhim shartlaridan biri bo'lgan sog'lom turmush tarzi tamoyillariga asoslanadi. Shu bilan birga, asosiy vazifalardan biri parhez ovqatlanish va ozuqa moddalar tarkibini optimallashtirish, aholi guruhlari va avvalambor, bolalar va o'smirlarning sog'lig'ini saqlash va yaxshilashdir. Ishning maqsadi umumiy o’rta ta’lim muassasalari o’quvchilarini sog’lom ovqatlanishini gigienik baholash va ularni optimallashtirish bo'yicha tavsiyalarni ilmiy asoslashdir. Aniqlanishicha, ovqatlanishda sanitariya qoida va me’yorlar bo'yicha bilimlarning yetarli emasligi bolalar va o'smirlarning ovqatlanishini tashkil etishdagi mavjud kamchiliklar, shuningdek iqtisodiy omillar tufayli ovqatlanish holatining yetarli emasligiga olib keladi.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7233AKADEMIK LITSEYLARDA FIZIKA FANIDAN INNOVATSION TEXNOLOGIYALARDAN FOYDALANGAN HOLATDA DARS O‘TISH2024-07-23T15:23:51+00:00Aliyev Nurjahon To‘xtamurod o‘g‘liinfo@pedagoglar.uzXoliqov Abror Abduvasiyevichinfo@web-journal.ruAralov Nurali Maxmudovichinfo@web-journal.ru<p><strong>Annotatsiya. </strong>Mazkur maqolada fizika fanini o‘qitishda innovatsion texnologiyalarning o‘rni haqida so‘z boradi. Muallif pedagogik ma’lumotlarga tayanib, mavjud ilmiy adabiyotlar asosida muammoni tahlil qilgan va fizika fanini o‘qitishda innovatsion texnologiyalarning o‘rni bo‘yicha mavjud o‘ziga xos jihatlarini o‘rgangan.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7111AKADEMIK LITSEYLARDA FIZIKA FANIDAN INNOVATSION TEXNOLOGIYALARDAN FOYDALANGAN HOLATDA DARS O‘TISH2024-07-23T15:23:32+00:00Aliyev Nurjahon To‘xtamurod o‘g‘liinfo@pedagoglar.uzXoliqov Abror Abduvasiyevichinfo@web-journal.ruAralov Nurali Maxmudovichinfo@web-journal.ru<p><strong>Annotatsiya. </strong>Mazkur maqolada fizika fanini o‘qitishda innovatsion texnologiyalarning o‘rni haqida so‘z boradi. Muallif pedagogik ma’lumotlarga tayanib, mavjud ilmiy adabiyotlar asosida muammoni tahlil qilgan va fizika fanini o‘qitishda innovatsion texnologiyalarning o‘rni bo‘yicha mavjud o‘ziga xos jihatlarini o‘rgangan.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7230MOLEKULALARNING TARTIBSIZ HARAKATI2024-07-23T15:23:50+00:00Xoliqov Abror Abduvasiyevichinfo@newjournal.orgAliyev Nurjahon To‘xtamurod o‘g‘liinfo@web-journal.ruAralov Nurali Maxmudovichinfo@pedagoglar.uz<p><strong>Annotatsiya. </strong>Ushbu maqolada molekulyar fizikaga oid ayrim qarashlar, shu jumladan molekulalarning tartibsiz harakatiga oid qarashlar muhokama etiladi.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7108MOLEKULALARNING TARTIBSIZ HARAKATI2024-07-23T15:23:31+00:00Xoliqov Abror Abduvasiyevichinfo@newjournal.orgAliyev Nurjahon To‘xtamurod o‘g‘liinfo@web-journal.ruAralov Nurali Maxmudovichinfo@pedagoglar.uz<p><strong>Annotatsiya. </strong>Ushbu maqolada molekulyar fizikaga oid ayrim qarashlar, shu jumladan molekulalarning tartibsiz harakatiga oid qarashlar muhokama etiladi.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7105ENERGIYANI AKKUMULYATSIYALASHNING O`ZIGA XOS JIHATLARI2024-07-23T15:23:31+00:00Aralov Nurali Maxmudovich info@pedagoglar.uzAliyev Nurjahon To‘xtamurod o‘g‘liinfo@pedagoglar.uzXoliqov Abror Abduvasiyevichinfo@pedagoglar.uz<p><strong>Annotatsіya. </strong>Іste’molchіnіng keragіdan ortіq mavjud energіyanі akkumulyatsіyalash (saqlash) jarayonі bіr muncha noіdeal holatda desak mubolag‘a bo‘lmaydі. Zero mavjud energіyanі saqlab qo‘yіsh orqalі, unі keraklі vaqtda va keraklі joyda іshlata olіsh muhіm masalalardan bіrіdіr.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7225ENERGIYANI AKKUMULYATSIYALASHNING O`ZIGA XOS JIHATLARI2024-07-23T15:23:49+00:00Aralov Nurali Maxmudovich info@pedagoglar.uzAliyev Nurjahon To‘xtamurod o‘g‘liinfo@pedagoglar.uzXoliqov Abror Abduvasiyevichinfo@pedagoglar.uz<p><strong>Annotatsіya. </strong>Іste’molchіnіng keragіdan ortіq mavjud energіyanі akkumulyatsіyalash (saqlash) jarayonі bіr muncha noіdeal holatda desak mubolag‘a bo‘lmaydі. Zero mavjud energіyanі saqlab qo‘yіsh orqalі, unі keraklі vaqtda va keraklі joyda іshlata olіsh muhіm masalalardan bіrіdіr.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7221UCH SHOHLI NERV VA UNING PATALOGIYASI2024-07-23T15:23:48+00:00Muxtorova S.info@web-journal.ruMaxammatova B.info@pedagoglar.uzXusanova M.Ainfo@pedagoglar.uz<p><strong>Annotatsiya:</strong> Mamlakatimiz tajribasini va eng yaxshi jahon yutuqlarini uyg‘unlashtirish asosida tibbiyot fanini rivojlantirish strategiyasini va prognozlashni ishlab chiqish, ilmiy-tibbiy tadqiqotlar samaradorligini oshirish, fan, texnika va ilg‘or tajriba yutuqlarini sog‘liqni saqlash amaliyotiga joriy qilish.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7102UCH SHOHLI NERV VA UNING PATALOGIYASI2024-07-23T15:23:31+00:00Muxtorova S.info@web-journal.ruMaxammatova B.info@pedagoglar.uzXusanova M.Ainfo@pedagoglar.uz<p><strong>Annotatsiya:</strong> Mamlakatimiz tajribasini va eng yaxshi jahon yutuqlarini uyg‘unlashtirish asosida tibbiyot fanini rivojlantirish strategiyasini va prognozlashni ishlab chiqish, ilmiy-tibbiy tadqiqotlar samaradorligini oshirish, fan, texnika va ilg‘or tajriba yutuqlarini sog‘liqni saqlash amaliyotiga joriy qilish.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7101THE SIGNIFICANCE OF ENDOTHELIAL DYSFUNCTION IN RHEUMATOID ARTHRITIS2024-07-23T15:23:31+00:00Musayeva Nargiza Baxtiyorovnainfo@web-journal.ru<p><strong>Abstract: </strong>In this article you can read about rheumatoid arthritis (RA) patients are at higher risk of accelerated atherosclerosis.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7219THE SIGNIFICANCE OF ENDOTHELIAL DYSFUNCTION IN RHEUMATOID ARTHRITIS2024-07-23T15:23:48+00:00Musayeva Nargiza Baxtiyorovnainfo@web-journal.ru<p><strong>Abstract: </strong>In this article you can read about rheumatoid arthritis (RA) patients are at higher risk of accelerated atherosclerosis.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7214DISTURBANCE IN THE HEMOSTATIC SYSTEM IN RHEUMATOID ARTHRITIS2024-07-23T15:23:47+00:00Musayeva Nargiza Baxtiyorovnainfo@web-journal.ru<p>Disturbance of fibrinolysis is common in rheumatoid arthritis (RA), and it may be associated with the increased cardiovascular risk observed in this population. We aimed to assess coagulation derangement and investigate whether abnormalities are influenced by demographic, inflammatory or metabolic factors in patients with RA. Levels of tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI-1), fibrinogen, prothrombin fragment 1 + 2 (PF1 + 2), thrombomodulin (TM), protein C and Von Willebrand factor (vWF) were compared between 141 RA patients and 50 healthy hospital controls. Within RA, coagulation factors were assessed alongside several demographic, inflammation and metabolic indicators. RA patients had higher levels of coagulation factors than controls. After correction for age and sex, having RA predicted increased tPA (B = 0.15, P < 0.001), PAI-1 (B = 0.21, P < 0.001), fibrinogen (B = 0.86, P < 0.001), PF1 + 2 (B = 0.20, P < 0.001), and TM (B = 0.01, P = 0.03) levels. CRP correlated positively with tPA (P < 0.05), fibrinogen (P < 0.001), TM (P < 0.05), PF1 + 2 (P < 0.001) and vWF (P < 0.001). Metabolic factors linked with coagulation factors were hypertriglyceridaemia (tPA, P < 0.05; PAI-1, P < 0.05; protein C, P < 0.05) and insulin resistance (tPA, P < 0.01; PAI-1, P < 0.01; vWF, P < 0.05). Imbalance of coagulation and fibrinolytic mechanisms is common in RA and associates with age, inflammation, and metabolic factors. Further studies may determine whether these abnormalities are the consequence of acute inflammation or markers of vascular dysfunction.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7099DISTURBANCE IN THE HEMOSTATIC SYSTEM IN RHEUMATOID ARTHRITIS2024-07-23T15:23:30+00:00Musayeva Nargiza Baxtiyorovnainfo@web-journal.ru<p>Disturbance of fibrinolysis is common in rheumatoid arthritis (RA), and it may be associated with the increased cardiovascular risk observed in this population. We aimed to assess coagulation derangement and investigate whether abnormalities are influenced by demographic, inflammatory or metabolic factors in patients with RA. Levels of tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI-1), fibrinogen, prothrombin fragment 1 + 2 (PF1 + 2), thrombomodulin (TM), protein C and Von Willebrand factor (vWF) were compared between 141 RA patients and 50 healthy hospital controls. Within RA, coagulation factors were assessed alongside several demographic, inflammation and metabolic indicators. RA patients had higher levels of coagulation factors than controls. After correction for age and sex, having RA predicted increased tPA (B = 0.15, P < 0.001), PAI-1 (B = 0.21, P < 0.001), fibrinogen (B = 0.86, P < 0.001), PF1 + 2 (B = 0.20, P < 0.001), and TM (B = 0.01, P = 0.03) levels. CRP correlated positively with tPA (P < 0.05), fibrinogen (P < 0.001), TM (P < 0.05), PF1 + 2 (P < 0.001) and vWF (P < 0.001). Metabolic factors linked with coagulation factors were hypertriglyceridaemia (tPA, P < 0.05; PAI-1, P < 0.05; protein C, P < 0.05) and insulin resistance (tPA, P < 0.01; PAI-1, P < 0.01; vWF, P < 0.05). Imbalance of coagulation and fibrinolytic mechanisms is common in RA and associates with age, inflammation, and metabolic factors. Further studies may determine whether these abnormalities are the consequence of acute inflammation or markers of vascular dysfunction.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7097THE SIGNIFICANCE OF ENDOTHELIAL DYSFUNCTION IN HEMORRHAGIC VASCULITIS2024-07-23T15:23:30+00:00Islamova Zulfiya Saidganixo'ja qiziinfo@pedagoglar.uz<p>Immunoglobulin A (IgA) vasculitis (IgAV), also known as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. It is characterized by cutaneous hemorrhage, resulting from red blood cell leakage into the skin or mucosae, possibly caused by damage to small blood vessels. These acute symptoms usually disappear without treatment. Endothelial cells are distributed on the inner surfaces of blood vessels and lymphatic vessels, and have important functions in metabolism and endocrine function, as well as being the primary targets of external stimuli and endogenous immune activity. Injury to endothelial cells is a feature of IgA vasculitis. Endothelial cell damage may be related to the deposition of immune complexes, the activation of complement, inflammatory factors, and chemokines, oxidative stress, hemodynamics, and coagulation factors. Both epigenetic mechanisms and genetic diversity provide a genetic background for endothelial cell injury. Here, research on the role of endothelial cells in allergic IgA vasculitis is reviewed.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7209THE SIGNIFICANCE OF ENDOTHELIAL DYSFUNCTION IN HEMORRHAGIC VASCULITIS2024-07-23T15:23:47+00:00Islamova Zulfiya Saidganixo'ja qiziinfo@pedagoglar.uz<p>Immunoglobulin A (IgA) vasculitis (IgAV), also known as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. It is characterized by cutaneous hemorrhage, resulting from red blood cell leakage into the skin or mucosae, possibly caused by damage to small blood vessels. These acute symptoms usually disappear without treatment. Endothelial cells are distributed on the inner surfaces of blood vessels and lymphatic vessels, and have important functions in metabolism and endocrine function, as well as being the primary targets of external stimuli and endogenous immune activity. Injury to endothelial cells is a feature of IgA vasculitis. Endothelial cell damage may be related to the deposition of immune complexes, the activation of complement, inflammatory factors, and chemokines, oxidative stress, hemodynamics, and coagulation factors. Both epigenetic mechanisms and genetic diversity provide a genetic background for endothelial cell injury. Here, research on the role of endothelial cells in allergic IgA vasculitis is reviewed.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7204DISTURBANCES IN THE HEMOSTATIC SYSTEM IN HEMORRHAGIC VASCULITIS2024-07-23T15:23:46+00:00Islamova Zulfiya Saidganixo'ja qiziinfo@web-journal.ru<p>In this article you can read about disturbances in the hemostatic system in hemorrhagic vasculitis.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7096DISTURBANCES IN THE HEMOSTATIC SYSTEM IN HEMORRHAGIC VASCULITIS2024-07-23T15:23:30+00:00Islamova Zulfiya Saidganixo'ja qiziinfo@web-journal.ru<p>In this article you can read about disturbances in the hemostatic system in hemorrhagic vasculitis.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7198MODERN METHODS OF TREATMENT FOR HEMORRHAGIC VASCULITIS2024-07-23T15:23:45+00:00Islamova Zulfiya Saidganixo'ja qizi info@web-journal.ru<p>Vasculitis poses a great diagnostic, investigative and therapeutic challenge to the treating physician. The classification of vasculitides itself still eludes universal acceptance. Comprehensive management comprises establishing the diagnosis of true vasculitis after ruling out vasculitis mimics, finding the etiology if feasible, assessing the caliber of the vessels involved, deciphering the pathological process of vessel damage, investigating for the existence and extent of systemic involvement and finally planning the therapy in the background of co-morbidities. Successful management also entails regular monitoring to foresee complications arising from the disease process itself as well as complications of immunosuppressive treatment. Although steroids remain first line drug, biologics are emerging as popular agents in the treatment of immune-mediated vasculitis. Triphasic treatment is the best plan of action comprising induction, maintenance of remission and treatment of relapses.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7095MODERN METHODS OF TREATMENT FOR HEMORRHAGIC VASCULITIS2024-07-23T15:23:29+00:00Islamova Zulfiya Saidganixo'ja qizi info@web-journal.ru<p>Vasculitis poses a great diagnostic, investigative and therapeutic challenge to the treating physician. The classification of vasculitides itself still eludes universal acceptance. Comprehensive management comprises establishing the diagnosis of true vasculitis after ruling out vasculitis mimics, finding the etiology if feasible, assessing the caliber of the vessels involved, deciphering the pathological process of vessel damage, investigating for the existence and extent of systemic involvement and finally planning the therapy in the background of co-morbidities. Successful management also entails regular monitoring to foresee complications arising from the disease process itself as well as complications of immunosuppressive treatment. Although steroids remain first line drug, biologics are emerging as popular agents in the treatment of immune-mediated vasculitis. Triphasic treatment is the best plan of action comprising induction, maintenance of remission and treatment of relapses.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7094MOLECULAR MECHANISMS OF DYSFUNCTION IN HEMORRHAGIC VASCULITIS2024-07-23T15:23:29+00:00Islamova Zulfiya Saidganixo'ja qiziinfo@web-journal.ru<p>Various pathogenic mechanisms have been implicated in the induction of vasculitis, including cell-mediated inflammation, immune complex-mediated inflammation and autoantibody-mediated inflammation.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7194MOLECULAR MECHANISMS OF DYSFUNCTION IN HEMORRHAGIC VASCULITIS2024-07-23T15:23:44+00:00Islamova Zulfiya Saidganixo'ja qiziinfo@web-journal.ru<p>Various pathogenic mechanisms have been implicated in the induction of vasculitis, including cell-mediated inflammation, immune complex-mediated inflammation and autoantibody-mediated inflammation.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7188CHANGES IN THROMBOCYTOGRAM INDICATORS AGAINST THE BACKGROUND OF ANTIVIRUS THERAPY IN PATIENTS WITH LIVER CIRRHOSIS WITH HCV ETIOLOGY2024-07-23T15:23:43+00:00Nuriddionova Nodira Fakhriddin kizi info@pedagoglar.uz<p>Nearly 290000 patients with chronic hepatitis C die annually from the most severe complications of the disease. One of them is liver cirrhosis, which occurs in about 20% of patients chronically infected with the hepatitis C virus (HCV). Direct-acting antivirals (DAAs), which replaced interferon (IFN)-based regimens, significantly improved the prognosis of this group of patients, increasing HCV eradication rates and tolerability of therapy. Our study is the first to assess changes in patient profile, effectiveness, and safety in the HCV-infected cirrhotic population in the IFN-free era.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7093CHANGES IN THROMBOCYTOGRAM INDICATORS AGAINST THE BACKGROUND OF ANTIVIRUS THERAPY IN PATIENTS WITH LIVER CIRRHOSIS WITH HCV ETIOLOGY2024-07-23T15:23:29+00:00Nuriddionova Nodira Fakhriddin kizi info@pedagoglar.uz<p>Nearly 290000 patients with chronic hepatitis C die annually from the most severe complications of the disease. One of them is liver cirrhosis, which occurs in about 20% of patients chronically infected with the hepatitis C virus (HCV). Direct-acting antivirals (DAAs), which replaced interferon (IFN)-based regimens, significantly improved the prognosis of this group of patients, increasing HCV eradication rates and tolerability of therapy. Our study is the first to assess changes in patient profile, effectiveness, and safety in the HCV-infected cirrhotic population in the IFN-free era.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7092SHAYX AHMAD TAROZIYNING ‘’FUNUN UL-BALOG’A” ASARI TUZILISHI VA G’OYAVIY MUNDARIJASI (DEVIN DE UISNING TADQIQOTI ASOSIDA)2024-07-23T15:23:28+00:00Muhiddinova Manzura Nuriddin qiziinfo@pedagoglar.uz<p><strong>Annotatsiya: </strong>Ushbu maqolada Temuriylar davri aruzshunosligiga doir ,,Funun ul-balog’a” risolasining tuzilishi hamda mazmuni AQSH dagi Indiana universiteti professori, sharqshunos olimi Devin de Uisning tadqiqoti asosida qisqacha tahlil qilingan.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7180SHAYX AHMAD TAROZIYNING ‘’FUNUN UL-BALOG’A” ASARI TUZILISHI VA G’OYAVIY MUNDARIJASI (DEVIN DE UISNING TADQIQOTI ASOSIDA)2024-07-23T15:23:42+00:00Muhiddinova Manzura Nuriddin qiziinfo@pedagoglar.uz<p><strong>Annotatsiya: </strong>Ushbu maqolada Temuriylar davri aruzshunosligiga doir ,,Funun ul-balog’a” risolasining tuzilishi hamda mazmuni AQSH dagi Indiana universiteti professori, sharqshunos olimi Devin de Uisning tadqiqoti asosida qisqacha tahlil qilingan.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7173ОСОБЕННОСТИ ПОЛИМОРФИЗМА ГЕНА ФАКТОРА НЕКРОЗА ОПУХОЛИ TNF- α (rs1800629) ПРИ АУТОИММУННОЙ ГЕМОЛИТИЧЕСКОЙ АНЕМИИ2024-07-23T15:23:41+00:00А.Х. Жахоновinfo@pedagoglar.uzД.С. Маткаримоваinfo@pedagoglar.uzА.Б. Саидовinfo@pedagoglar.uzЛ.Д. Саматоваinfo@newjournal.orgЖалилов Ф.С.info@pedagoglar.uz<p><strong>Введение.</strong> На сегодня известно, что в механизмах формирования патологий человека, в том числе и аутоиммунной гемолитической анемии (АИГА), важная роль принадлежит полиморфным генам, регулирующие в организме сложные процессы приводя к развитию заболевания [2,3]. Особое внимание исследователей уделяется изучению степени участия полиморфных локусов генов TNF-α (rs1800629) в патогенезе АИГА [5,7].</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7090ОСОБЕННОСТИ ПОЛИМОРФИЗМА ГЕНА ФАКТОРА НЕКРОЗА ОПУХОЛИ TNF- α (rs1800629) ПРИ АУТОИММУННОЙ ГЕМОЛИТИЧЕСКОЙ АНЕМИИ2024-07-23T15:23:28+00:00А.Х. Жахоновinfo@pedagoglar.uzД.С. Маткаримоваinfo@pedagoglar.uzА.Б. Саидовinfo@pedagoglar.uzЛ.Д. Саматоваinfo@newjournal.orgЖалилов Ф.С.info@pedagoglar.uz<p><strong>Введение.</strong> На сегодня известно, что в механизмах формирования патологий человека, в том числе и аутоиммунной гемолитической анемии (АИГА), важная роль принадлежит полиморфным генам, регулирующие в организме сложные процессы приводя к развитию заболевания [2,3]. Особое внимание исследователей уделяется изучению степени участия полиморфных локусов генов TNF-α (rs1800629) в патогенезе АИГА [5,7].</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7088INGLIZ TILI DARSLARIDA TINGLAB TUSHUNISH KO’NIKMASINI O’QITISH YUZASIDAN KELIB CHIQADIGAN QIYINCHILIKLAR VA METODLAR2024-07-23T15:23:27+00:00Qudratova Layloinfo@pedagoglar.uz<p><strong> A</strong><strong>nnotatsiya:</strong> Ushbu maqolada ingliz tilining tinglab tushunish ko’nikmasini rivojlantirishda o’rganuvchilar duch keladigan qiyinchiliklari yuzasidan izlanishlar olib borilganligi natijalari tahlil qilinadi. Bundan tashqari bunday muammolarni yengish usullari haqida fikr yuritiladi.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7170INGLIZ TILI DARSLARIDA TINGLAB TUSHUNISH KO’NIKMASINI O’QITISH YUZASIDAN KELIB CHIQADIGAN QIYINCHILIKLAR VA METODLAR2024-07-23T15:23:40+00:00Qudratova Layloinfo@pedagoglar.uz<p><strong> A</strong><strong>nnotatsiya:</strong> Ushbu maqolada ingliz tilining tinglab tushunish ko’nikmasini rivojlantirishda o’rganuvchilar duch keladigan qiyinchiliklari yuzasidan izlanishlar olib borilganligi natijalari tahlil qilinadi. Bundan tashqari bunday muammolarni yengish usullari haqida fikr yuritiladi.</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7162WEB-SAHIFADA MATN JOYLASHTIRISH VA ULARNI BOSHQARISH. LINK JOYLASHTIRISH2024-07-23T15:23:39+00:00Farog'at Maxmudova Shag'darovnainfo@pedagoglar.uz<p> <strong> Annotatsiya.</strong> Ushbu maqola veb-sahifalarda matnni samarali joylashtirish va boshqarishning muhim jihatlarini o'rganadi. Axborot asosan internetda iste'mol qilinadigan bugungi raqamli asrda matn tarkibini taqdim etishni optimallashtirish foydalanuvchini jalb qilish va qoniqish uchun juda muhimdir. Maqolada veb-sahifalarning o'qilishi va qulayligini oshirish uchun turli xil strategiyalar, shu jumladan havolalarni joylashtirish kiradi</p>2024-01-15T00:00:00+00:00Copyright (c) 2024 http://pedagoglar.uz/index.php/ped/article/view/7087WEB-SAHIFADA MATN JOYLASHTIRISH VA ULARNI BOSHQARISH. LINK JOYLASHTIRISH2024-07-23T15:23:26+00:00Farog'at Maxmudova Shag'darovnainfo@pedagoglar.uz<p> <strong> Annotatsiya.</strong> Ushbu maqola veb-sahifalarda matnni samarali joylashtirish va boshqarishning muhim jihatlarini o'rganadi. Axborot asosan internetda iste'mol qilinadigan bugungi raqamli asrda matn tarkibini taqdim etishni optimallashtirish foydalanuvchini jalb qilish va qoniqish uchun juda muhimdir. Maqolada veb-sahifalarning o'qilishi va qulayligini oshirish uchun turli xil strategiyalar, shu jumladan havolalarni joylashtirish kiradi</p>2024-01-15T00:00:00+00:00Copyright (c) 2024